Saturday, February 11, 2006
[evomech] Regulatory gene networks and the properties of the developmental process (PNAS)
[Davidson et al., PNAS, Feb '03]
Abstract:
Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.
Full text at:
http://www.pnas.org/cgi/content/full/100/4/1475
John
Please Note: If you are reading this in a Blog then replying directly to this message (as opposed to making a 'blog comment') requires membership of the 'Evolution: Where Darwin meets Lamarck?' Egroup at:
http://groups.yahoo.com/group/evomech/
Abstract:
Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.
Full text at:
http://www.pnas.org/cgi/content/full/100/4/1475
John
Evolution: Where Darwin meets Lamarck? Discussion Forum:
http://groups.yahoo.com/group/evomech
technorati tags: dna, genetics, regulatory, development, transcription
Please Note: If you are reading this in a Blog then replying directly to this message (as opposed to making a 'blog comment') requires membership of the 'Evolution: Where Darwin meets Lamarck?' Egroup at:
http://groups.yahoo.com/group/evomech/
Add to: CiteUlike | Connotea | Del.icio.us | Digg | Furl | Newsvine | Reddit | Yahoo
